Researchers have developed the first comprehensive atlas of allele-specific DNA methylation across 39 human cell types, revealing a complex landscape of epigenetic regulation. The study identified ...

A noninvasive urinary DNA methylation test demonstrated high sensitivity for detecting high-grade or invasive bladder cancer. A urinary DNA methylation test displayed superior sensitivity for ...

The epigenetic modification, DNA methylation, is characterized by 5-methylcytosine (5-mC) and found in specific genomic locations, most notably regulatory regions such as promoters and enhancers.

Prevalence of androgen receptor ligand-binding domain mutations (AR-LBDm) in circulating tumor DNA (ctDNA) versus tissue biopsies in participants (pts) with metastatic castration-resistant prostate ...

"We find that epigenetic clocks based on the entropy of methylation states predict chronological age with similar accuracy as common approaches that are based on methylation levels of individual ...

Development of a Composite Score Based on Carbohydrate Antigen 19-9 Dynamics to Predict Survival in Carbohydrate Antigen 19-9–Producing Patients With Pancreatic Ductal Adenocarcinoma After Neoadjuvant ...

The race for early cancer detection is one that physicians have been running for millennia. In one of humanity’s oldest surviving medical texts, the ancient Egyptian physician Imhotep described 46 ...

A new DNA methylation-based blood test can identify type 2 diabetes patients at the highest risk of heart attack or stroke years in advance, beating traditional risk scores and opening the door to ...

Women are often juggling work, family, and social roles, leaving little time for their own health. The modern genetic and ...