Here we describe repressible (PipOFF) as well as inducible (PipON) systems for regulated gene expression in mammalian cells, based on the repressor Pip (pristinamycin-induced protein), which is ...

Using structural biology and synthetic chemistry, scientists are bolstering the armament of streptogramin antibiotics. This class of bacteria fighters has largely been abandoned, in part because of ...

Daniel J. Blair is in the Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, USA. Read the paper: Synthetic group A streptogramin antibiotics that overcome ...